Dr. Mahesh Desai acquired his M.B.B.S. degree in 1966 from B.J. Medical College, Ahmedabad and his M.S. in General Surgery from Pune University. In 1973, he received a fellowship from the Royal College of Surgeons of London and Edinburgh, where he obtained specialized training in Urology. He returned to India to start his practice and establish the importance of modern treatment for various kidney diseases in Ahmedabad. In collaboration with Dr V. V. Desai, he established Muljibhai Patel Urological Hospital (MPUH) at Nadiad, a rural area in the state of Gujarat in India. Desai aimed to help men with adequate medical facilities concerning their urological diseases.
He performed more than 20000 PCNLs himself and described the 'Microperc' technique in 2011 in which percutaneous renal access and lithotripsy are performed in a single step using a 16 G micropuncture needle for safe and efficient in the management of small renal calculi in adult and pediatric population. It can also be used for renal calculi in ectopic kidneys and bladder calculi. The high stone clearance rate and lower complication rate associated with microperc make it a viable alternative to retrograde intrarenal surgery.